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KMID : 0624620140470020115
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BMB Reports
2014 Volume.47 No. 2 p.115 ~ p.120
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The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4
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Lee Su-Jung
Noh Kyung-Tae
Kang Tae-Heung
Han Hee-Dong
Shin Sung-Jae
Soh Byoung-Yul
Park Jung-Hee
Shin Yong-Kyoo
Kim Han-Wool
Yun Cheol-Heui
Park Won-Sun
Jung In-Duk
Park Yeong-Min
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Abstract
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In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-α, and IL-1β) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform na?ve T cells to polarized CD4+ and CD8+ T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. paratuberculosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of CD4+ and CD8+ T cells.
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KEYWORD
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Dendritic cells, MAPKs, MAP1305, Mycobacterium avium subsp. paratuberculosis, Th1 polarization
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